DuoCoat™

Novel enteric coating technology for precise GI targetting 

Conventional enteric coatings designed to release drug in the proximal small intestine normally require up to 2 hours post-gastric emptying to disintegrate. This invariably causes a significant delay in drug absorption and can compromise the bioavailability of drugs which have a narrow absorption window in the upper GI tract.

In addition, drug delivery to the ileo-colonic regions using common enteric coated systems has often proved unsuccessful because of the failure of these polymers to disintegrate and release drug prior to dosage form elimination. DuoCoat™ is a proprietary technology (“solid dosage forms comprising an enteric coating with accelerated drug release” WO/2008/135090) that is clinically proven to accelerate the dissolution rate of enteric coatings and can be applied to almost all conventional dosage forms for all of your GI targeting needs.

Key benefits of DuoCoat™:

• Clinically proven technology protected by a strong patent portfolio
• Cost effective - uses standard EU and FDA approved coating materials
• Can be applied to a variety of conventional dosage forms, inc. tablets, capsules, granules, pellets and mini-tablets
• Provides rapid drug release in the small intestine to afford faster onset of action compared to current commercial enteric coatings. Ideal for Proton-Pump Inhibitors (PPIs) or drugs to treat acute pain
• Enhanced bioavailability of drugs with narrow absorption windows in the proximal small intestine
• Enhanced bioavailability of poorly soluble basic compounds (allows local delivery in a pre-solubilised form to avoid drug precipitation post gastric emptying)
• Improved targeting of drugs to the ileo-colonic region for local or systemic action
  

DuoCoat™ can be accessed either as a fee-for-service program or through technology license. Please contact us directly for more information.